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Whilst small-count MBL seldom progresses to CLL, substantial-rely MBL progresses to CLL necessitating therapy at a charge of 1% to 2% per year. High-count MBL is distinguished from Rai 0 CLL based on whether or not the B-mobile rely is over or beneath five × 109/L. Whilst people today with both equally significant-rely MBL and CLL Rai stage 0 are at increased threat of infections and next cancers, the potential risk of development necessitating procedure and the possible to shorten life expectancy are larger for CLL. This critique highlights hard issues regarding the classification, danger stratification, administration, and supportive care of patients with LINK ALTERNATIF MBL77 MBL and CLL.
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